China (Mainland)
Synthetic penicillin acylase / Amidase CAS NO.9014-06-6
- Min.Order: 0 Metric Ton
- Payment Terms: L/C,D/A,D/P,T/T
- Product Details
Keywords
- Immobilized penicillin amidase
- Immobilized penicillin acylase
- Synthetic Penicillin acylase
Quick Details
- ProName: Synthetic penicillin acylase / Amidase
- CasNo: 9014-06-6
- Port: Beijing /Shanghai /Tianjin
- ProductionCapacity: Metric Ton/Day
- Purity: 80%
- LimitNum: 0 Metric Ton
Superiority
Penicillin G Acylase
Rate of Conversion more than 170
Rate of Side-Chain less than 1.02
| Function |
|---|
| catalytic activity |
| hydrolase activity |
| Process |
| physiological process |
| metabolism |
| cellular metabolism |
| drug metabolism |
| antibiotic metabolism |
| antibiotic biosynthesis |
Details
Synthetic Penicillin acylase introduction
Penicillin acylase(E.C 3.5.1.11) is the enzyme used commercially for the production of semisyntheticβ-lactam antibiotics and their intermediates. The industrial production of β-lactam antibiotics and their intermediates is undergoing a remarkable transformation traditional chemical conversions based on stoichiometry are being replaced by enzyme-catalyzed processes.
A general production chart of penicillin-derived antibiotics(semi-synthetic penicillins, SSPs, e.g., amoxicillin and ampicillin) and cephalosporin-derived antibiotics (semi-synthetic cephalosporins ,SSCs, e.g., cefadroxil and cephalexin) is outlined in scheme.
The high S/H(synthesis/hydrolysis) ratio in synthesis reactions is compared to commercially available immobilized penicillin acylase. Industrial semi-synthetic antibiotics result from the condensation of a modified side –chain (the acyl donor) to a β-latam nucleus. For example amoxicillin , conversion: 6-APA > 99%, 6-APA:HPGMe≤1.02
Cas:9014-06-6
